By the 16th century, the Inca empire had seen many years of strong leadership. Huayna Capac, the Inca in power when Europeans began to arrive in South America, was respected and admired throughout the empire.

Both Huayna Capac and his designated heir died, most likely of smallpox. The ensuing war of succession between the Panakas (royal lines) weakened the Inca leadership and contributed to its speedy downfall. At the centre of the conflict were the two main contenders,Huascar and Atahualpa, who were both sons of Huayna Capac.

Huascar may have been named the new emperor, though no records remain to confirm that he was indeed the intended heir. Regarded as ugly, bad-mannered and half-mad, Huascar was known for his cruelty and came close to murdering his sister and mother. Nonetheless, he was well-liked in the southern regions of the empire. Atahualpa, on the other hand, was chosen to govern the northern territory known as the Kingdom of Quito, which was located in modern-day Ecuador and southern Colombia.

After a few years of relative peace, war broke out between the two brothers. It is estimated that 100,000 people were killed in this bloodthirsty dispute known as the War of the Two Brothers. After many struggles, Atahualpa finally defeated Huascar. Atahualpa himself teetered towards insanity and treated the losers terribly. Many had stones dropped on their backs to cripple them, fetuses were ripped from wombs and bodies were stuck on spikes for display, and nearly 1,500 members of the royal family were cut up in front of Huascar, including his own children.